Purified anti-ERK1/2 Phospho (Thr202/Tyr204) Antib-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 293	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Synthetic peptide (TGFLT*EY*VATRC) conjugated to KLH.

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

Affinity purified.

Concentration

0.5 mg/ml

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICC - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 ?g per ml.?For immunocytochemistry, a concentration of 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Weiss JM, et al. 2018. J Clin Invest. 128:3794. PubMed
McFall T, et al. 2021. Cell Rep. 37:110096. PubMed
Vaquero M, et al. 2019. J Am Soc Nephrol. 30:1398. PubMed
McFall T, et al. 2022. NPJ Precis Oncol. 6:86. PubMed
Anerillas C, et al. 2022. Sci Adv. 8:eabm0756. PubMed
Anerillas C, et al. 2022. Nat Commun. 13:6228. PubMed

RRID

AB_2565604 (BioLegend Cat. No. 675502)

Antigen Details

Structure: Human ERK1 (MAPK3) and ERK2 (MAPK1) encode 43, 40, 38kD and 41, 36kD protein kinases, respectively. Mouse ERK1 (MAPK3) and ERK2 (MAPK1) encode 43kD and 41kD protein kinases, respectively. ERK1 and ERK2 share high homology.
Distribution: Cytoplasm. Nucleus.
Function: ERK1/2 are broadly expressed protein kinases that are involved in proliferation, differentiation, motility, and cell death. In response to extracellular stimuli, ERK1/2 are phosphorylated at Thr202 and Tyr204 and in turn transduce signals to downstream substrates.
Interaction: ERK1/2 phosphorylates a wide range of downstream substrates, such as ATF2, BCL6, EIF4EBP1, CANX, MAP2, DAPK1, RAF1, SYK, and GRB10.
Biology Area: Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
Molecular Family: Phospho-Proteins, Postsynaptic proteins, Protein Kinases/Phosphatase
Antigen References: 1. Futran AS, et al. 2013. Curr. Biol. 23:R972.
2. Mendoza MC, et al. 2011. Trends Biochem. Sci. 36:320.
3. Chambard JC, et al. 2007. Biochim. Biophys. Acta. 1773:1299.
4. Roux PP, et al. 2004. Microbiol. Mol. Biol. Rev. 68:320.
5. Torii S, et al. 2004. J. Biochem. 136:557.
6. Clark EA, et al. 1996. J. Biol. Chem. 271:14814.
Gene ID: 5594 View all products for this Gene ID
UniProt: View information about ERK1/2 Phospho on UniProt.org

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