HRP anti-TPP1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 147	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant mature human TPP1 expressed in E. coli.

Formulation

This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.

Preparation

The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.

Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml. For immunohistochemistry, a concentration range of 1.0 - 5.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone does not recognize rodent (mouse or rat) TPP1.

Application References (PubMed link indicates BioLegend citation)

Wujek P, et al. 2004. J. Biol. Chem. 279:12827-39.

RRID

AB_2783421 (BioLegend Cat. No. 852203) AB_2783422 (BioLegend Cat. No. 852204)

Antigen Details

Structure

Human TPP1 is a 563 amino acid protein with a molecular mass of 61 kD. An isoform of 34.5 kD and 320 amino acids (244-563) is generated by alternative splicing.

Distribution

Tissue sources: Ubiquitously expressed. Highest levels in heart, placenta, bone marrow, lung, pineal, and lymphocytes.
Cellular distribution: Lysosome and extracellular.

Function

TPP1 cleaves tripeptides from the N-termini of substrates in lysosomes and has endopeptidase activity.

Interaction

CLN5.

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Proteases, Enzymes and Regulators

Antigen References