FITC anti-mouse MERTK (Mer) Antibody
- 产品名称：
- FITC anti-mouse MERTK (Mer) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 151503
- 产品应用：
- 151503
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse MERTK extracellular domain
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
- Product Citations
-
- Zhu B, et al. 2021. Immunity. 54(6):1200-1218.e9. PubMed
- Wang H, et al. 2022. Curr Protoc. 2:e446. PubMed
- Bagayoko S, et al. 2021. PLoS Pathog. 17:e1009927. PubMed
- Aegerter H, et al. 2020. Nat Immunol. 0.975694444. PubMed
- Penke LR, et al. 2020. Life Sci Alliance. 3:. PubMed
- Ryu S, et al. 2021. eLife. 0.416666666666667. PubMed
- Zhang J, et al. 2020. Cell Metabolism. 31(6):1136-1153. PubMed
- RRID
- AB_2617034 (BioLegend Cat. No. 151503) AB_2617035 (BioLegend Cat. No. 151504)
- Structure
- Member of the TAM (TYRO3/AXL/MerTK) family. Encodes a transmembrane protein, two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain.
- Distribution
-
Macrophages, monocytes, and dendritic cells.
- Function
- Regulates TLR signaling, efferocytosis, phagocytosis, cell survival, and macrophage migration. Inhibits production of inflammatory cytokines.
- Interaction
- Grb2, LimD4, and Vav1.
- Ligand/Receptor
- LGALS3, TUB, TULP1, and GAS6.
- Cell Type
- Dendritic cells, Macrophages, Monocytes
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Toll Like Receptors
- Antigen References
-
1. Zagórska A, et al. 2014. Nat. Immunol. 15:920.
2. Toda S, et al. 2014. Blood 123:3963.
3. Chung WS, et al. 2013. Nature 504:394.
4. Carrera Silva EA, et al. 2013. Immunity 39:160.
5. Yi Z, et al. 2009. Blood 114:3191.
- Gene ID
- 17289 View all products for this Gene ID
- UniProt
- View information about MERTK on UniProt.org
