Purified anti-Ataxin-3 Antibody
- 产品名称：
- Purified anti-Ataxin-3 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 650401
- 产品应用：
- 650401
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length Ataxin-3 recombinant protein
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 0.5 ?g per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Zhou L, et al. 2013. Neuroscience. 23:243. PubMed
- Product Citations
-
- Chapman TP, et al. 2019. Front Immunol. 1.454861111. PubMed
- Zhou L, et al. 2013. Neuroscience. 23:243. PubMed
- RRID
- AB_10900236 (BioLegend Cat. No. 650401) AB_10900992 (BioLegend Cat. No. 650402)
- Structure
- 364 aa with predicted molecular weight of 42 kD. The protein contains highly polymorphic polyglutamine repeats and has two isoforms which contain 2 or 3 ubiquitin interacting motifs (UIMs).
- Distribution
-
Nuclear
- Function
- Has transcriptional repression activity through interaction with regulators of transcription and histones. It regulates ER-associated protein degradation and autophagy when interacts with p97/VCP. It also contains deubiquitination activity.
- Interaction
- Ataxin-3 interacts with ubiquitin, p97/VCP, histone acetyl-transferases (p300, CBP, and PCAF), and histone.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors, Ubiquitin/Protein Degradation
- Antigen References
-
1. Kawaguchi Y, et al. 1994. Nat. Genet. 3:213.
2. Mao Y, et al. 2005. P. Natl. Acad. Sci. USA 102:12700.
3. Li F, et al. 2002. J. Biol. Chem. 277:45004.
4. Zhong X, et al. 2006. Hum. Mol. Genet. 15:2409.
5. Tait D, et al. 1998. Hum. Mol. Genet. 7:991.
- Gene ID
- 110616 View all products for this Gene ID
- UniProt
- View information about Ataxin-3 on UniProt.org
