Purified anti-TICAM-1 (TRIF) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 265	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human TICAM-1 recombinant protein (29-204 a.a.)

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICC, IP, IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0??g per ml.?For immunocytochemistry, a concentration of 5.0 μg/ml is recommended. For immunoprecipitation, the suggested use of this reagent is 2.0 - 10 μg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Oldenburg R, et al. 2018. Front Immunol. 9:2. PubMed
Bhattacharjee P, et al. 2018. Sci Rep. 13:e0199785. PubMed
Liu Z, et al. 2021. Immunity. 54(2):247-258.e7. PubMed

RRID

AB_2562543 (BioLegend Cat. No. 657102)

Antigen Details

Structure: 712 amino acids, predicted molecular weight of 76 kD. Contains a Toll/interleukin-1 receptor (TIR) homology domain responsible for mediating protein-protein interactions.
Distribution: Cytosol, endosome membrane
Function: TICAM-1 acts as an adaptor protein of TLR3 and TLR4 (through TRAM), mediating innate immune responses during viral infection.
Interaction: TICAM-1 interacts with TLR3, TRAM, TBK1, IRF3, IRF7, TRAF3, TRAF6, and IKKi.
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience
Molecular Family: Toll Like Receptors
Antigen References: 1. Petnicki-Ocwieja T, et al. 2013. Infect Immun. 81:402.
2. Riad A, et al. 2011. J. Immunol. 186:2561.
3. Choi YJ, et al. 2010. J. Biol. Chem. 285:21382.
4. Gais P, et al. 2010. J. Immunol. 184:5842.
5. Han KJ, et al. 2010. J. Biol. Chem. 285:12543.
6. Takeda K and Akira S. 2005. Int. Immunol. 17:1.
Gene ID: 148022 View all products for this Gene ID
UniProt: View information about TICAM-1 on UniProt.org

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