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首页 > 抗体蛋白 > 抗体
Purified anti-RUNX1 Antibody
产品名称：
Purified anti-RUNX1 Antibody
产品类别：
抗体
产品编号：
659302
产品应用：
659302
[价格]
规格 价格 库存
100µg ￥ 265 1

产品详情

Product Details

Verified Reactivity
Human
Reported Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Partial human RUNX1 recombinant protein (191-350 aa) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
ICC, IP - Verified
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 ?g per mL.?For immunoprecipitation, the suggested use of this reagent is 10 - 30 μg per mL. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).

This product weakly reacts with Mouse.

Product Citations
  1. Canu G, et al. 2020. Genome Biol. 0.984027778. PubMed
  2. Li M, et al. 2021. Nat Commun. 12:420. PubMed
  3. Takao S, et al. 2021. eLife. 10:00. PubMed
  4. Bouchard G, et al. 2022. Cancer Res. 82:648. PubMed
RRID
AB_2563194 (BioLegend Cat. No. 659302)

Antigen Details

Structure
453 amino acids encode a protein with a predicted MW of 48.7 kD. Contains a Runt domain responsible for DNA binding.
Distribution

Nucleus.

Function
RUNX1 is a transcription factor that plays crucial roles in hematopoiesis, hair follicle development, neurogenesis, chondrogenesis, and leukemogenesis.
Interaction
Interacts with TLE1, ELF1, ELF2, ELF4, SPI1, KAT6A, KAT6B, YAP1, and CDK6. Forms a heterodimer with CBFB.
Cross
Human, Cross-Reactivity: Mouse (weak)
Cell Type
B cells, Neural Stem Cells, Neutrophils
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells, Transcription Factors
Antigen References

1. Goyama S, et al. 2013. J. Clin. Invest. 123:3876.
2. Wang J, et al. 2013. PLoS One. 18:e74255.
3. Taniuchi I, et al. 2012. EMBO J. 31:4098.
4. Neel BG, et al. 2012. Genes Dev. 26:1520.
5. Della Gatta G, et al. 2012. Nat. Med. 18:436.
6. Hoi CS, et al. 2010. Mol. Cell Biol. 30:2518.

Gene ID
861 View all products for this Gene ID
UniProt
View information about RUNX1 on UniProt.org

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