Brilliant Violet 421™ anti-GATA3 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 182	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial human GATA3 recombinant protein (1-258 aa).

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).

Preparation

The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

ICFC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet?.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.

Excitation Laser

Violet Laser (405 nm)

Product Citations

Di Blasi D, et al. 2019. Cell Mol Gastroenterol Hepatol. 0.510416667. PubMed
Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
Green CD et al. 2018. Developmental cell. 46(5):651-667 . PubMed
Tuganbaev T, et al. 2020. Cell. 182(6):1441-1459.e21. PubMed
Galle-Treger L, et al. 2016. Nat Commun. 7:13202. PubMed
Feng J,et al. 2017. Nat Commun. . 10.1038/s41467-017-01056-8. PubMed
Giampazolias E, et al. 2021. Cell. . PubMed
Gu BH, et al. 2019. J Immunol. 203:349. PubMed
Kim M, et al. 2018. Immunity. 49:151. PubMed
Wang R, et al. 2022. J Immunother Cancer. 10:. PubMed
Cho SX, et al. 2020. Nat Commun. 4.481944444. PubMed

RRID

AB_2563220 (BioLegend Cat. No. 653813) AB_2563221 (BioLegend Cat. No. 653814)

Antigen Details

Structure: 48 kD protein containing two GATA-type zinc finger domains responsible for DNA binding and two trans-activating domains at N-terminus.
Distribution: Nucleus
Function: GATA3, a transcriptional activator, binds to a consensus DNA sequence 5'-(A/T)GATA(A/G)-3' in the promoter region of genes, regulates T cell development, T_H2 cell differentiation, and luminal cell proliferation.
Interaction: Interacts with Smad3, FOG1, FOG2, and PU.1.
Biology Area: Cell Biology, Chromatin Remodeling/Epigenetics, Immunology, Signal Transduction, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Yagi R, et al. 2011. Int. Immunol. 23:415.
2. Chou J, et al. 2010. J. Cell Physiol. 222:42.
3. Ho IC, et al. 2009. Nat. Rev. Immunol. 9:125.
4. Rothenberg EV, et al. 2008. Semin. Immunol. 20:236.
5. Kouros-Mehr H, et al. 2008. Curr. Opin. Cell Biol. 20:164.
6. Van Esch H, et al. 2000. Nature 406:419.
Gene ID: 2625 View all products for this Gene ID 14462 View all products for this Gene ID
UniProt: View information about GATA3 on UniProt.org

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