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首页 > 抗体蛋白 > 抗体
Purified anti-Artemis Antibody
产品名称：
Purified anti-Artemis Antibody
产品类别：
抗体
产品编号：
691602
产品应用：
691602
[价格]
规格 价格 库存
100µg ￥ 3542 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Partial human Artemis recombinant protein (347-692 aa) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody has a similar affinity to BioLegend clone 13A9C90 for human Artemis by western blot, but does not recognize mouse Artemis

Product Citations
  1. Niewolik D, et al. 2022. Nucleic Acids Res. 50:2096. PubMed
RRID
AB_2632653 (BioLegend Cat. No. 691602)

Antigen Details

Structure
692 amino acids with a predicted molecular weight of 78.4 kD. Four isoforms produced by alternative splicing.
Distribution

Nucleus.

Function
Artemis is a nuclear protein exhibiting single-strand-specific 5'-3' exonuclease activity and endonuclease activity. It plays crucial roles in V(D)J recombination and DNA repair.
Interaction
Interacts with ATM, BRCA1, PRKDC and TP53BP1.
Biology Area
Cell Biology, DNA Repair/Replication
Antigen References

1. Chang HH, et al. 2016. Nucleic Acids Res. 44:4991.
2. Volk T, et al. 2015. Hum. Mol. Genet. 24:7361.
3. Waide EH, et al. 2015. J. Immunol. 195:3171.
4. Lee PP, et al. 2013. Clin. Immunol. 149:464.
5. K?cher S, et al. 2012. Nucleic Acids Res. 40:8336.
6. Beucher A, et al. 2009. EMBO J. 28:3413.

Gene ID
64421 View all products for this Gene ID
UniProt
View information about Artemis on UniProt.org

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