Go-ChIP-Grade™ Purified anti-HDAC2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3626	1

Product Details

Verified Reactivity: Human, Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human HDAC2 peptide (471-488 a.a.) conjugated to KLH.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: ChIP - Quality tested
WB, IP, ICC, KO/KD-WB - Verified
Recommended Usage: Each lot of this antibody is quality control tested by ChIP Assay. The suggested dilution for ChIP application is 1:50-1:100 by volume.?For Western blotting, the suggested use of this reagent is 0.5 - 2.5 ?g per ml.?For immunoprecipitation, the suggested use of this reagent is 10 - 30 μg per ml. For immunocytochemistry, a concentration range of 0.1 - 10 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: 25 ?g and?100 ?g of Go-ChIP-Grade? Purified Antibody can be used for 2-5 or 10-20 immunoprecipitations, respectively, at the recommended dilutions.
RRID: AB_2632842 (BioLegend Cat. No. 680104)

Structure: 488 amino acids with a predicted molecular weight of 55.4 kD. It contains a histone deacetylase domain.
Distribution: Widely expressed in many cell types; nucleus.
Function: HDAC2 is a histone deacetylase responsible for the deacetylation of ??-amino acid group of lysine residues on the N-terminal tail of core histones (H2A, H2B, H3, H4). HDAC2 forms complex with transcription factors and acts as a transcriptional co-repressor.
Interaction: Forms histone deacetylase complexes with HDAC1, RBBP4, and RBBP7. Interacts with GFI1, SNW1, HDAC7, PRDM6, SAP30, SETDB1, SUV39H1, H2AFY, ATR, CBFA2T3, BCL-6, DNMT1, MINT, HDAC10, HCFC1, NRIP1, KDM4A, TSHZ3 and PELP1.
Biology Area: Cell Biology, Chromatin Remodeling/Epigenetics, Transcription Factors
Antigen References: 1. Winter M, et al. 2013. EMBO J. 32:3176.
2. Ma P, et al. 2013. PLoS Genet. 9:e1003377.
3. Kurita M, et al. 2012. Nat. Neurosci. 15:1245.
4. Segre CV, et al. 2011. J. Biomed. Biotechnol. 2011:690848.
5. Brunmeir R, et al. 2009. Int. J. Dev. Biol. 53:275.
6. Guan JS, et al. 2009. Nature 459:55.
Gene ID: 3066 View all products for this Gene ID
UniProt: View information about HDAC2 on UniProt.org