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首页 > 抗体蛋白 > 抗体
Purified anti-Granzyme B Antibody
产品名称：
Purified anti-Granzyme B Antibody
产品类别：
抗体
产品编号：
662801
产品应用：
662801
[价格]
规格 价格 库存
25µg ￥ 1414 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Partial mouse Granzyme B recombinant protein (17-247 aa) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Anthony SM, et al. 2021. eLife. 10:00. PubMed
RRID
AB_2564373 (BioLegend Cat. No. 662801) AB_2564374 (BioLegend Cat. No. 662802)

Antigen Details

Structure
227 amino acids with predicted molecular weight of 25.3 kD in mature form.
Distribution
Secreted.
Function
Granzyme B can induce target cell apoptosis by activating caspase independent pathways. It is induced in CD8+ T cells with ConA/ IL-2 and CD4+ T cells with anti CD3/CD28 or CD3/CD46.
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroscience
Molecular Family
Proteases, Enzymes and Regulators
Antigen References

1. Edwards KM, et al. 1999. J. Biol. Chem. 274:30468.
2. Grossman WJ, et al. 2004. Blood 104:2840.
3. Heusel JW, et al. 1994. Cell 76:977.
4. Schmid J and Weissmann C. 1987. J. Immunol. 139:250.
5. Trapani JA, et al. 1988. Proc. Natl. Acad. Sci. USA 85:6924.
6. Hiebert PR and Granville DJ. 2012. Trends Mol. Med. 18:732.
7. Saito Y, et al. 2011. J. Cardiol. 57:141.

Gene ID
14939 View all products for this Gene ID
UniProt
View information about Granzyme B on UniProt.org

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