Purified anti-IRF3 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1736	1

Product Details

Verified Reactivity

Human, Mouse

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Partial IRF-3 recombinant protein (200-427 a.a.)

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

Affinity purified

Concentration

0.5 mg/ml

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
ChIP - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. For ChIP applications, the suggested dilution is 1:50-1:100 by volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

He X, et al. 2017. PLoS One. 13(6):e1006347. PubMed
Kanno T, et al. 2022. Front Immunol. 13:904875. PubMed
Raychowdhury R, et al. 2021. Immunohorizons. 5:818. PubMed

RRID

AB_2562201 (BioLegend Cat. No. 655701) AB_2562202 (BioLegend Cat. No. 655702)

Antigen Details

Structure: Human IRF-3 has 427 amino acids with predicted Mw 47.2kD and observed Mw 52kD. Contains an IRF tryptophan pentad repeat responsible for DNA binding. Mouse Irf-3 has 419 amino acids with predicted MW 46.9kD and observed Mw 45kD.
Distribution: Inactive IRF-3 continuously transits between the cytoplasm and nucleus. Serine/threonine phosphorylation or IRF-3 results in the structural changes which allow IRF-3 activation. The activated IRF3 translocates to the nucleus, where it forms a complex with CREB binding protein and activates the transcription of interferons, interferon stimulated genes, and other antiviral response genes.
Function: IRF-3 is a constitutively expressed, latent transcription factor that plays a pivotal role in type I IFN response.
Interaction: CREB binding protein, IRF-7, TICAM-1, TICAM-2, non-canonical IKB kinases TBK1 and IKKε.
Biology Area: Cell Biology, Immunology, Innate Immunity, Signal Transduction, Transcription Factors
Molecular Family: Nuclear Markers
Antigen References: 1. Lin R, et al. 1999. Mol. Cell Biol. 19:959.
2. Hiscott J, et al. 2007. J. Biol. Chem.?282:15325.
3. Molle C, et al. 2010. J. Immunol. 184:1784.
Gene ID: 3661 View all products for this Gene ID
UniProt: View information about IRF3 on UniProt.org

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