Purified anti-human CD223 (LAG-3) Antibody
- 产品名称：
- Purified anti-human CD223 (LAG-3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 369302
- 产品应用：
- 369302
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human LAG-3 transfected cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The staining of clone 11C3C65 cannot be blocked by clone 7H2C65, which is another anti-human CD223 (LAG-3) antibody.
- Product Citations
-
- Gide TN, et al. 2019. Cancer Cell. 35:238. PubMed
- Tian Y, et al. 2019. Cell Rep. 29:4482. PubMed
- Liu F, et al. 2020. J Immunother Cancer. 8:. PubMed
- O'Boyle KC, et al. 2020. Methods Mol Biol. 2111:1. PubMed
- Cobb DA, et al. 2022. J Immunother Cancer. 10:. PubMed
- Schulte–Schrepping J, et al. 2020. Cell. 182(6):1419-1440. PubMed
- Macmillan ML, et al. 2021. Blood Adv. 5:1425. PubMed
- Georg P, et al. 2022. Cell. 185:493. PubMed
- RRID
- AB_2616876 (BioLegend Cat. No. 369302)
- Structure
- 70 kD transmembrane glycoprotein, Ig superfamily, highly homologous to CD4.
- Distribution
-
Activated T-cells and natural killer cells (NKs) and regulatory T cells.
- Function
- Negatively regulates T-cell activation.
- Ligand/Receptor
- Binds MHC class II molecules.
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Castelli C, et al. 2014. Oncoimmunology. 3(11):e967146.
2. Poirier N, et al. 2011. Clin. Exp. Immunol. 164:265.
3. Juno JA, et al. 2015. Retrovirology. 12:17.
4. Casati C, et al. 2006. Cancer Res. 66:4450.
- Gene ID
- 3902 View all products for this Gene ID
- UniProt
- View information about CD223 on UniProt.org
