FITC anti-human CD223 (LAG-3) Antibody
- 产品名称：
- FITC anti-human CD223 (LAG-3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 369307
- 产品应用：
- 369307
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2226 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human LAG-3 transfected cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
- Application Notes
The staining of clone 11C3C65 cannot be blocked by clone 7H2C65, which is another anti-human CD223 (LAG-3) antibody.
- Product Citations
-
- Kuo HH, et al. 2018. Immunity. 48:1183. PubMed
- Bhattacharya P, et al. 2020. Elife. 9:00. PubMed
- Müller TR, et al. 2021. Cell Rep Med. 2:100374. PubMed
- Mathewson ND, et al. 2021. Cell. 184(5):1281-1298.e26. PubMed
- Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed
- Song TY, et al. 2021. Nat Commun. 12:7003. PubMed
- Zou F, et al. 2019. Nat Commun. 10:4109. PubMed
- Gamradt S, et al. 2021. iScience. 24:103312. PubMed
- RRID
- AB_2629750 (BioLegend Cat. No. 369307) AB_2629751 (BioLegend Cat. No. 369308)
- Structure
- 70 kD transmembrane glycoprotein, Ig superfamily, highly homologous to CD4.
- Distribution
-
Activated T-cells and natural killer cells (NKs) and regulatory T cells.
- Function
- Negatively regulates T-cell activation.
- Ligand/Receptor
- Binds MHC class II molecules.
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Castelli C, et al. 2014. Oncoimmunology. 3(11):e967146.
2. Poirier N, et al. 2011. Clin. Exp. Immunol. 164:265.
3. Juno JA, et al. 2015. Retrovirology. 12:17.
4. Casati C, et al. 2006. Cancer Res. 66:4450.
- Gene ID
- 3902 View all products for this Gene ID
- UniProt
- View information about CD223 on UniProt.org
