Brilliant Violet 421™ anti-human CD223 (LAG-
- 产品名称：
- Brilliant Violet 421™ anti-human CD223 (LAG-
- 产品类别：
- 抗体
- 产品编号：
- 369313
- 产品应用：
- 369313
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2926 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human LAG-3 transfected cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421? under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
Brilliant Violet 421? excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421? is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet?.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
- Violet Laser (405 nm)
- Application Notes
The staining of clone 11C3C65 cannot be blocked by clone 7H2C65, which is another anti-human CD223 (LAG-3) antibody.
- Product Citations
-
- Wang H, et al. 2022. Front Immunol. 13:852436. PubMed
- Zah E, et al. 2020. Nat Commun. 11:2283. PubMed
- Warmuth S, et al. 2022. Oncoimmunology. 10:2004661. PubMed
- Paul S, et al. 2021. Sci Transl Med. 13:. PubMed
- Si J, et al. 2020. Cancer Cell. 38(4):551-566.e11. PubMed
- Darcis G, et al. 2020. Cell Rep. 30:2284. PubMed
- Suzuki S, et al. 2020. Cancer Sci. 1943:111. PubMed
- Juillerat A, et al. 2020. Front Bioeng Biotechnol. 0.804166667. PubMed
- Deng W, et al. 2021. Emerg Microbes Infect. 10:1272. PubMed
- RRID
- AB_2629796 (BioLegend Cat. No. 369313) AB_2629797 (BioLegend Cat. No. 369314)
- Structure
- 70 kD transmembrane glycoprotein, Ig superfamily, highly homologous to CD4.
- Distribution
-
Activated T-cells and natural killer cells (NKs) and regulatory T cells.
- Function
- Negatively regulates T-cell activation.
- Ligand/Receptor
- Binds MHC class II molecules.
- Cell Type
- Dendritic cells, NK cells, T cells, Tregs
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Castelli C, et al. 2014. Oncoimmunology. 3(11):e967146.
2. Poirier N, et al. 2011. Clin. Exp. Immunol. 164:265.
3. Juno JA, et al. 2015. Retrovirology. 12:17.
4. Casati C, et al. 2006. Cancer Res. 66:4450.
- Gene ID
- 3902 View all products for this Gene ID
- UniProt
- View information about CD223 on UniProt.org
