Purified anti-FGF-1-acidic Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3206	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Parital human human FGF-1 recombinant protein (16-155 a.a.) expressed in E. coli.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2565906 (BioLegend Cat. No. 678602)

Antigen Details

Structure: The 140 amino acid recombinant protein has a predicted molecular mass of approximately 16 kD. Growth factor.
Distribution: Secreted. FGF-1 is widely expressed in developing and adult tissues.
Function: FGF-1 plays an important role in many biological processes, including cell proliferation, inflammation, and angiogenesis. FGF-1 has a low stability and a very short half-life in vivo. Binding to heparin increases the stability of FGF-1 and is also important for the formation of active FGF-acidic/FGFR complex.
Interaction: Intracellular FGF-1 can interact directly with CK2, FIBP, mortalin, and the ribosome-binding protein p34/leucine-rich repeat containing 59 (LRRC59).
Ligand/Receptor: FGF-1 can signal through all known cell-surface FGFR isoforms (FGFR1b, 1c, 2b, 2c, 3b, 3c, and 4). FGF-1 also binds to heparin and heparin sulfate proteoglycans on the cell surface.
Biology Area: Angiogenesis, Cell Biology, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, Growth Factors, Cytokines/Chemokines
Antigen References: 1. Presta M, et al. 2005. Cytokine Growth Factor Rev. 2:159.
2. Zakrzewska M, et al. 2008. Crit. Rev. Clin. Lab. Sci. 45:91.
3. Zhang L, et al. 1997. Oncogene. 15:2093.
4. Lin YZ, et al. 1996. J. Biol. Chem. 271:5305.
5. Culajay JF, et al. 2000. Biochemistry 39:7153.
6. Cassina P, et al. 2005. J. Neurochem. 93:38.
7. Pehar M, et al. 2005. Neurodegener. Dis. 2:139.
8. Jonker JW, et al. 2012. Nature 485:391.
9. Compagni A, et al. 2000. Cancer Res. 60:7163.
Gene ID: 2246 View all products for this Gene ID
UniProt: View information about FGF-1-acidic on UniProt.org

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