Purified anti-STAT1 Antibody
- 产品名称：
- Purified anti-STAT1 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 661001
- 产品应用：
- 661001
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 ?g per ml (1:500). For immunoprecipitation, the suggested use of this reagent is 2.0 ?g/test.It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).
- Product Citations
-
- Martin–Fernandez M, et al. 2020. Cell Reports. 31(6):107633. PubMed
- RRID
- AB_2563663 (BioLegend Cat. No. 661001) AB_2563664 (BioLegend Cat. No. 661002)
- Structure
- 750 amino acids, predicted molecular weight of 87 kD; contains a SH2 domain responsible for homodimerization or heterodimerization.
- Distribution
-
Cytoplasm; phosphorylated form translocates to the nucleus.
- Function
- Phosphorylated in response to cytokine signaling by receptor-associated kinases; translocates to the nucleus to act as a transcription factor. Mediates responses to type I (IFN-α/β) and II interferon (IFN-γ), EGF, PDGF, and IL-6.
- Interaction
- Forms a homodimer or heterodimers with other family members. Interacts with FAK, MCM3, MCM5, TRADD, BRCA1, KIT, IL-27R, IL-2Rβ, IL-2Rγ, IFNαβR, and c-Src.
- Cell Type
- Mesenchymal Stem Cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Signal Transduction, Stem Cells, Transcription Factors
- Antigen References
-
1. Durbin JE, et al. 1996. Cell 8:443.
2. Darnell JE Jr, et al. 1994. Science 264:1415.
3. Chen X, et al. 1998. Cell 93:827.
4. Ramana CV, et al. 2000. Oncogene 19:2619.
- Gene ID
- 6772 View all products for this Gene ID
- UniProt
- View information about STAT1 on UniProt.org
