Purified anti-Wntless (GPR177) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4858	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Human Wntless protein

Formulation

This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Storage & Handling

Upon receipt, store undiluted between 2°C and 8°C.

Application

WB - Quality tested
ICC, IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The clone recognizes a ~65 kD protein of unidentified origin.

Additional reported applications (for relevant formats) include: immunoprecipitation (IP)¹ and immunocytochemistry (ICC)¹

Application References (PubMed link indicates BioLegend citation)

Coombs GS, et al. 2010. J. Cell Sci. 123:3357. (ICC, IP)

Product Citations

Wesslowski J, et al. 2020. J Biol Chem. 295:8759. PubMed
Glaeser K, et al. 2018. EMBO J. 37:. PubMed

RRID

AB_2562228 (BioLegend Cat. No. 655902)

Antigen Details

Structure: Three isoforms with 450 to 543 amino acids, predicted molecular weight of 45-65 kD; structure similar to the member of G-protein coupled receptor (GPCR) superfamily, with conserved YXXΦ endocytotic motif
Distribution: Cytoplasmic organelles
Function: Regulates Wnt protein sorting and secretion; it plays a key role in the regulation of expression, subcellular localization, binding and organelle-specific association of Wnt proteins
Interaction: Interacts with WNT1, WNT3, WNT5A, and Vps35
Ligand/Receptor: Wnt
Biology Area: Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication, Immunology, Signal Transduction
Antigen References: 1. Hardin J and King RS,?et al. 2008. Curr. Opin. Genet. Dev. 18:362.
2. Wang LT, et al.?2012. Kaohsiung J. Med. Sci. 28:355.
3. Cornett B, et al. 2013. Dev. Biol. 2013. 379:38.
4. Das S, et al. 2012. Front. Biol. (Beijing). 7:587.
5. Stefater JA 3rd, et al. 2013. Blood?121:2574.
Gene ID: 79971 View all products for this Gene ID
UniProt: View information about Wntless on UniProt.org

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