PE anti-mouse GITR Ligand Antibody
- 产品名称：
- PE anti-mouse GITR Ligand Antibody
- 产品类别：
- 抗体
- 产品编号：
- 120305
- 产品应用：
- 120305
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse GITRL protein and Transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
- Lu LF, et al. 2005. J. Immunol. 175:1651
- Esparza EM and RH Arch. 2005. J. Immunol. 174:7875
- Ray A, et al. 2012. J. Immunol. 188:3188. PubMed.
- Product Citations
-
- Hinks TSC, et al. 2019. Cell Rep. 28:3249. PubMed
- Ray A, et al. 2012. J Immunol. 188:3188. PubMed
- Zhang M, et al. 2017. Mol Med Rep. 15:4291. PubMed
- RRID
- AB_2287690 (BioLegend Cat. No. 120305) AB_2207248 (BioLegend Cat. No. 120306)
- Structure
- TNF superfamily member
- Distribution
-
B cells, macrophages, dendritic cells, endothelial cells.
- Function
- Bind GITR receptor to co-stimulate T cells activation, proliferation, and cytokine production; inhibit the suppressive activities of CD4+CD25+ Treg cells.
- Ligand/Receptor
- GITR (TNFRSF18)
- Cell Type
- B cells, Macrophages, Dendritic cells, Endothelial cells, Tregs
- Biology Area
- Immunology
- Antigen References
-
1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.
2. Kim JD, et al. 2003. Genes Immun. 4:564.
3. Yu KY, et al. 2003. Biochem. Biophys. Res. Commun. 310:433.
4. Shin HH, et al. 2002. Cytokine 19:187.
- Gene ID
- 240873 View all products for this Gene ID
- UniProt
- View information about GITRL on UniProt.org
