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首页 > 抗体蛋白 > 抗体
PE/Cyanine7 anti-mouse CD357 (GITR) Antibody
产品名称：
PE/Cyanine7 anti-mouse CD357 (GITR) Antibody
产品类别：
抗体
产品编号：
120222
产品应用：
120222
[价格]
规格 价格 库存
100µg ￥ 4858 1

产品详情

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse GITR protein and Transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 120216).

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.
Application References

(PubMed link indicates BioLegend citation)
  1. Cobbold SP, et al. 2004. J. Immunol. 172:6003.
  2. Biburger M, et al. 2008. J. Leukocyte Biol. 84:264. PubMed
Product Citations
  1. Willingham SB, et al. 2018. Cancer Immunol Res. 6:1136. PubMed
  2. An J, et al. 2022. iScience. 25:103570. PubMed
  3. Yue X, et al. 2019. Nat Commun. 10:2011. PubMed
  4. Andersen L, et al. 2020. Cell Reports. 29(13):4447-4459.e6.. PubMed
  5. Kumagai S, et al. 2020. Immunity. 53(1):187-203.e8. PubMed
RRID
AB_528907 (BioLegend Cat. No. 120222)

Antigen Details

Structure
TNF receptor superfamily member
Distribution

Low levels on resting T cells, high on CD4+CD25+ Treg cells, expression upregulated upon activation.

Function
Co-stimulate GITR expressing cells activation, proliferation, and cytokine production; inhibit the suppressive activities of CD4+CD25+ Treg cells.
Ligand/Receptor
GITR ligand (TNFSF18)
Cell Type
T cells, Tregs
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References

1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
2. Ronchetti S, et al. 2004. Eur. J. Immunol. 34:613
3. Kanamaru F, et al. 2004. J. Immunol. 172:613
4. Shimizu J, et al. 2002. Nat. Immunol. 3:135
5. Stephens GL, et al. 2004. J. Immunol. 173:5008
6. McHugh RS, et al. 2002. Immunity 16:311

Gene ID
21936 View all products for this Gene ID
UniProt
View information about CD357 on UniProt.org

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