Alexa Fluor® 488 anti-mouse CD357 (GITR) Antib-上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 4858	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Recombinant mouse GITR protein and Transfected cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 10⁶cells in 100 ?l staining volume. It is recommended that the reagent be titrated for optimal performance for each application.

* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.

Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

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Application Notes

The LEAF? purified antibody (Endotoxin <0.1 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 120216).

Application References (PubMed link indicates BioLegend citation)

Cobbold SP, et al. 2004. J. Immunol. 172:6003.
Biburger M, et al. 2008. J. Leukocyte Biol. 84:264. PubMed

Product Citations

Iype T, et al. 2010. J Immunol. 185:6115. PubMed

RRID

AB_439727 (BioLegend Cat. No. 120211)

Antigen Details

Structure: TNF receptor superfamily member
Distribution: Low levels on resting T cells, high on CD4⁺CD25⁺ Treg cells, expression upregulated upon activation.
Function: Co-stimulate GITR expressing cells activation, proliferation, and cytokine production; inhibit the suppressive activities of CD4⁺CD25⁺ Treg cells.
Ligand/Receptor: GITR ligand (TNFSF18)
Cell Type: T cells, Tregs
Biology Area: Immunology, Costimulatory Molecules
Molecular Family: CD Molecules
Antigen References: 1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
2. Ronchetti S, et al. 2004. Eur. J. Immunol. 34:613
3. Kanamaru F, et al. 2004. J. Immunol. 172:613
4. Shimizu J, et al. 2002. Nat. Immunol. 3:135
5. Stephens GL, et al. 2004. J. Immunol. 173:5008
6. McHugh RS, et al. 2002. Immunity 16:311
Gene ID: 21936 View all products for this Gene ID
UniProt: View information about CD357 on UniProt.org

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