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Alexa Fluor® 488 anti-human CD31 Antibody
产品名称：
Alexa Fluor® 488 anti-human CD31 Antibody
产品类别：
抗体
产品编号：
303109
产品应用：
303109
[价格]
规格 价格 库存
25tests ￥ 1736 1

产品详情

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor? 488 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

* Alexa Fluor? 488 has a maximum emission of 519 nm when it is excited at 488 nm.


Alexa Fluor? and Pacific Blue? are trademarks of Life Technologies Corporation.

View full statement regarding label licenses
Excitation Laser
Blue Laser (488 nm)
Application Notes

Clone WM59 has been reported to recognize the D2 extracellular portion of CD31.

Additional reported applications (for the relevant formats) include: immunofluorescence microscopy2, immunohistochemical staining of acetone-fixed frozen tissue sections8,?blocking of platelet aggregation3, and spatial biology (IBEX)11,12. Clone WM59 is not recommended for immunohistochemical staining of formalin-fixed paraffin-embedded sections. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 303143 & 303144).

The purified WM59 antibody is useful as a capture antibody for a sandwich ELISA assay, when used in conjunction with biotin anti-human CD31 antibody (Cat. No. 536604) antibody as the detection antibody.

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossman S, et al. Eds. 1995. Leucocyte Typing V Oxford University Press. New York.
  2. Muczynski KA, et al. 2003. J. Am. Soc. Nephrol. 14:1336. (IF)
  3. Wu XW, et al. 1997. Arterioscl. Throm. Vas. 17:3154. (Block)
  4. Nagano M, et al. 2007. Blood 110:151. (FC) PubMed
  5. MacFadyen JR, et al. 2005. FEBS Lett. 579:2569. PubMed
  6. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  7. Sestak K, et al. 2007. Vet. Immunol. Immunopathol. 119:21.
  8. Wicki A, et al. 2012. Clin. Cancer Res. 18:454. (FC, IHC) PubMed
  9. Oeztuerk-Winder F, et al. 2012. EMBO J. 31:3431. (FC) PubMed
  10. Bushway ME, et al. 2014. Biol Reprod. 90(5): 110 (IF) PubMed
  11. Radtke AJ,?et al. 2020.?Proc Natl Acad Sci USA. 117:33455-33465. (SB)?PubMed
  12. Radtke AJ,?et al. 2022.?Nat Protoc. 17:378-401. (SB)?PubMed
Product Citations
  1. Jeon NL, et al. 2020. Biotechnol Bioeng. 117:748. PubMed
  2. Hu-Lowe D, et al. 2011. Cancer Res. 71:1362. PubMed
  3. Chen W, et al. 2021. Nat Microbiol. 6:455. PubMed
  4. Nishino K, et al. 2021. Sci Rep. 11:8406. PubMed
  5. Bradfield P, et al. 2016. PLoS One. 11: 0159679. PubMed
  6. Ajit A, et al. 2020. J Biomed Mater Res B Appl Biomater. 108:2807. PubMed
  7. Qi J, et al. 2022. Nat Commun. 13:1742. PubMed
  8. Sarkar TJ, et al. 2020. Nat Commun. 11:1545. PubMed
  9. Judson RN et al. 2018. Cell stem cell. 22(2):177-190 . PubMed
  10. Hallett JM, et al. 2022. Cell Stem Cell. 29:355. PubMed
  11. Quarta M, et al. 2016. Nat Biotechnol. 10.1038/nbt.3576. PubMed
  12. Khan OF, et al. 2018. Sci Adv. 4:eaar8409. PubMed
  13. Harvestine JN, et al. 2018. J Mater Chem B. 6:4104. PubMed
  14. Park D, et al. 2021. Sci Rep. 11:19986. PubMed
  15. Hedegaard CL, et al. 2020. Sci Adv. 6:00. PubMed
  16. Harvestine JN, et al. 2020. Sci Adv. 6:eaay2387. PubMed
  17. Joly P, et al. 2017. PLoS One. 12(6):e0180568. PubMed
  18. Ajit A, et al. 2019. Tissue Eng Part C Methods. 25:148. PubMed
  19. Xu J, et al. 2017. Clin Cancer Res. 23:4482. PubMed
  20. Meng YM, et al. 2018. Oncoimmunology. 7:e1408745. PubMed
  21. Tsukada Y, et al. 2021. Sci Rep. 0.975694444. PubMed
  22. Kumashiro Y, et al. 2015. Small. 6: 681 - 687. PubMed
  23. Teijeira á, et al. 2020. Immunity. 52(5):856-871. PubMed
  24. Antonyshyn JA, et al. 2021. Commun Biol. 4:1205. PubMed
RRID
AB_493075 (BioLegend Cat. No. 303109) AB_493074 (BioLegend Cat. No. 303110)

Antigen Details

Structure
Ig superfamily, type I transmembrane glycoprotein, 130-140 kD
Distribution

Monocytes, platelets, granulocytes, endothelial cells, lymphocyte subset

Function
Cell adhesion, signal transduction
Ligand/Receptor
CD38
Cell Type
Endothelial cells, Granulocytes, Lymphocytes, Monocytes, Neutrophils, Platelets
Biology Area
Angiogenesis, Cell Adhesion, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References
  1. DeLisser H, et al. 1994. Immunol. Today 15:490.
  2. Newman P, 1997. J. Clin. Invest. 99:3.
  3. Fawcett J, et al. 1995. J. Cell Biol. 128:1229.
Gene ID
5175 View all products for this Gene ID
UniProt
View information about CD31 on UniProt.org

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