PE anti-human CD126 (IL-6Rα) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1806	1

Product Details

Verified Reactivity

Human

Reported Reactivity

African Green, Baboon, Cynomolgus, Rhesus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Human myeloma cell line U266

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.

Application References (PubMed link indicates BioLegend citation)

Huang YW and Vitetta ES. 1993. Hybridoma 12:621.

Product Citations

Csomós I, et al. 2021. Int J Mol Sci. 22:. PubMed
Zhang G, et al. 2020. Am J Transplant. 20:999. PubMed
Ferreira R, et al. 2013. PLoS Genet. 9:1003444. PubMed
Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
Perrigue P, et al. 2015. Mol Cancer Res. 13:636. PubMed
Eriksson E, et al. 2019. J Immunol. 202:787. PubMed
Saga R, et al. 2019. Oncol Lett. 17:3555. PubMed
Van Zeebroeck L, et al. 2021. Front Immunol. 12:655122. PubMed
Alasady MJ, et al. 2021. PLoS One. 16:e0256238. PubMed
Salameh JW, et al. 2022. Bioengineering (Basel). 9:. PubMed

RRID

AB_10897103 (BioLegend Cat. No. 352803) AB_10900066 (BioLegend Cat. No. 352804)

Antigen Details

Structure: Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD
Distribution: Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts
Function: Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation
Interaction: CD130, c-Src, STAT3, WWP1, WWP2
Ligand/Receptor: IL-6
Cell Type: B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797.
2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London.
3. Boulanger MJ, et al. 2003. Science 300:2101.
4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820.
Gene ID: 3570 View all products for this Gene ID
UniProt: View information about CD126 on UniProt.org

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