APC/Fire™ 750 anti-human HLA-DR, DP, DQ Anti
- 产品名称：
- APC/Fire™ 750 anti-human HLA-DR, DP, DQ Anti
- 产品类别：
- 抗体
- 产品编号：
- 361711
- 产品应用：
- 361711
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2394 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- Baboon, Cynomolgus, Cat, Dog, Cow
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human PBL
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC/Fire? 750 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
* APC/Fire? 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
- Excitation Laser
- Red Laser (633 nm)
- Application Notes
Tü39 has been reported to react with a shared epitope of HLA-DR, HLA-DP, and HLA-DQ.
Additional reported applications (of relevant formats) include immunoprecipitation6, in vitro blocking of MLR5, and suppressor cell generation4. The LEAF? purified antibody (Endotoxin <0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (contact our custom solutions team).
- Application References
(PubMed link indicates BioLegend citation) -
- Pawelec G, et al. 1985. Hum. Immunol. 12:165.
- Shaw S, et al. 1985. Hum. Immunol. 12:191.
- Ziegler A, et al. 1986. Immunobiology 171:77.
- Pawelec G, et al. 1986. Hum. Immunol. 17:343. (Block)
- Dai Z, et al. 2009. J. Exp. Med. 206:793. (Block)
- Pawelec G, et al. 1988. J. Exp. Med. 167:243. (IP)
- RRID
- AB_2750313 (BioLegend Cat. No. 361711) AB_2750314 (BioLegend Cat. No. 361712)
- Structure
- Ig superfamily, MHC class II, heterodimeric transmembrane protein
- Distribution
-
B cells, activated T cells, monocytes/macrophages, dendritic cells, other APCs
- Function
- Antigen presentation
- Ligand/Receptor
- CD3/TCR, CD4
- Cell Type
- Antigen-presenting cells, B cells, Dendritic cells, Macrophages, Monocytes, T cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
-
1. Thorsby E. 1974. Transplant. Rev.?18:51.
2. Qvigstad E, et al. 1984. Hum. Immunol. 11:207.
3. Servenius B, et al. 1984. EMBO J. 3:3209.
4. Ottenhoff TH, et al. 1985. Hum. Immunol. 13:105.
5. Strassmann G, et al. 1985. Hum. Immunol. 13:125.
6. Trowsdale J, et al. 1985. Immunol Rev. 85:5.
- Gene ID
- 3122 View all products for this Gene ID 3123 View all products for this Gene ID 3113 View all products for this Gene ID 3115 View all products for this Gene ID 3117 View all products for this Gene ID 3119 View all products for this Gene ID
- UniProt
- View information about HLA-DR, DP, DQ on UniProt.org
