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Purified anti-human HLA-DQ Antibody
产品名称:
Purified anti-human HLA-DQ Antibody
产品类别:
抗体
产品编号:
361502
产品应用:
361502
[价格]
规格 价格 库存
100µg ¥ 2716 1

产品详情

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human PBL
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Tü169 has been reported to react with HLA-DQ1 and HLA-DQ2. It also shows weak reactivity to HLA-DQ3.

Additional reported applications (for the relevant formats) include: immunofluorescence2 and in vitro blocking1. The LEAF? purified antibody (Endotoxin < 0.1 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (contact our custom solutions team).

Application References

(PubMed link indicates BioLegend citation)
  1. Benagiano M, et al. 2012. Proc. Natl. Acad. Sci. USA 109:1222. (Block)
  2. Rees LE, et al. 2003. Clin. Exp. Immunol. 134:497. (IF)
  3. Nasi A, et al. 2013. J. Immunol. 191:3090. (FC)
  4. Turrini R, et al. 2011. Cancer Immunol. Immunother. 60:1639. (FC)
Product Citations
  1. Chang SH, et al. 2019. Exp Mol Med. 51:28. PubMed
  2. Song S, et al. 2021. Front Immunol. 12:705140. PubMed
  3. Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed
RRID
AB_2563137 (BioLegend Cat. No. 361502)

Antigen Details

Structure
Ig superfamily, MHC class II, heterodimeric transmembrane protein
Distribution

B cells, activated T cells, monocytes/macrophages, dendritic cells, other APCs

Function
Antigen presentation
Ligand/Receptor
CD3/TCR, CD4
Cell Type
Antigen-presenting cells, B cells, Dendritic cells, Macrophages, Monocytes, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
MHC Antigens
Antigen References

1. Thorsby E. 1974. Transplant. Rev.?18:51.
2. Qvigstad E, et al. 1984. Hum. Immunol. 11:207.
3. Servenius B, et al. 1984. EMBO J. 3:3209.
4. Ottenhoff TH, et al. 1985. Hum. Immunol. 13:105.
5. Strassmann G, et al. 1985. Hum. Immunol. 13:125.
6. Trowsdale J, et al. 1985. Immunol. Rev. 85:5.
7. Dorman J, et al. 2000. Epidemiologic Reviews?22:218.
8. van Lith M,?et al. 2010. J. Biol. Chem. 285:40800.

Gene ID
3117 View all products for this Gene ID 3119 View all products for this Gene ID
UniProt
View information about HLA-DQ on UniProt.org

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