Purified anti-mouse CD73 Antibody
- 产品名称:
- Purified anti-mouse CD73 Antibody
- 产品类别:
- 抗体
- 产品编号:
- 117202
- 产品应用:
- 117202
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- BALB/c mouse splenocytes and CHO cells transfected with the mouse CD73 gene, Nt5
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 ?g per million cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The TY/23 antibody has been reported to inhibit the enzymatic activity of CD73.
- Application References
(PubMed link indicates BioLegend citation) -
1. Zhang B. 2010. Cancer Res. 70:6407-11.??
2. Stagg J, et al. 2010. Proc Natl Acad Sci U S A. 107:1547-52.
3. Forte G, et al. 2012. J Immunol. 189:2226-33.
- Structure
- 69 kD GPI-anchored surface protein
- Distribution
-
Positive on most CD11b+ myeloid cells in bone marrow, but not on CD11b+ peripheral cells; a large proportion of CD4+ and CD8+ splenic T cells express CD73
- Function
- A nucleotidase catalyzing the dephosphorylation of extracellular nucleoside 5' monophosphates
- Ligand/Receptor
- Nucleoside 5' monophosphate
- Cell Type
- B cells, Mesenchymal Stem Cells, Tregs
- Biology Area
- Costimulatory Molecules, Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
-
- Yamashita Y, et al. 1998. Eur J?Immunol. 28:2981-90.
- Resta R, et al. 1998. Immunol?Rev.?161:95-109.
- Gene ID
- 23959 View all products for this Gene ID
- UniProt
- View information about CD73 on UniProt.org