APC anti-mouse CD155 (PVR) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1918	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

CD155 transfectants

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.

Concentration

0.2 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser

Red Laser (633 nm)

Application References (PubMed link indicates BioLegend citation)

Tahara-Hanaoka S, et al. 2004. Int. Immunol. 16:533.
Maier MK, et al. 2007. Eur. J. Immunol.. 37:2214.
Bottino C, et al. 2003. J. Exp. Med. 198:557.
Dressel R, et al. 2010. FASEB J. 9:134. PubMed

Product Citations

Du X, et al. 2018. Proc Natl Acad Sci U S A. 115:E11731. PubMed
Wang N, et al. 2020. Front Immunol. 1.765972222. PubMed

RRID

AB_10640453 (BioLegend Cat. No. 131509) AB_10645507 (BioLegend Cat. No. 131510)

Antigen Details

Structure: 70 kd immunoglobulin-like molecule with three Ig-like domains.
Distribution: CD155 is expressed at cell junctions on the primary vascular endothelial cells. Moreover, mouse CD155 is highly expressed on DP thymocytes and expression level is dropped in peripheral single positive CD4⁺ and CD8⁺ T cells. CD155 can be detected on T reg, other activated T cells and on NKT cells. Resident monocytes express moderate amount of CD155, but upregulated its expression during inflammation. Other cells, such as IEL, neutrophils and subsets of B cells were found to express CD155 to varying extents.
Function: Apart from its function of adhering junction among contacting epithelial cells, the interaction of DNAM-1 (CD226) with its ligands CD155 and CD112 (nectin 2) induces cytotoxcity of NK cells and CD8⁺ T cells and cytokine secretion.
Ligand/Receptor: CD226 (DNAM-1), CD96
Cell Type: B cells, Endothelial cells, Neutrophils, Thymocytes, Tregs
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules, Immune Checkpoint Receptors
Antigen References: 1. Mendelsohn C, et al. 1989. Cell 56:855.
Gene ID: 52118 View all products for this Gene ID
UniProt: View information about CD155 on UniProt.org

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