Purified anti-human CD112 (Nectin-2) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 1736	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications include: partially block CD226-Fc binding to CD112 transfectant cells and partially inhibit the cytotoxicity mediated by NK and T cells.

Application References (PubMed link indicates BioLegend citation)

Tahara-Hanaoka S, et al.. 2004. Int. Immunol. 16:533
Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
Gillory LA, 2013. PLoS One. 8:77753. PubMed

RRID

AB_2174164 (BioLegend Cat. No. 337402)

Antigen Details

Structure: Type I transmembrane glycoprotein, Ig superfamily
Distribution: Myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells.
Function: Adhesion, receptor for some Herpes Viruses
Ligand/Receptor: CD226, CD155, Nectin-1, -3, and -4, Herpes Viruses
Cell Type: Dendritic cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, Mast cells, Megakaryocytes
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Zola H et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Bachelet I, et al. 2006. J. Bio. Chem. 281:27190
3. Pende D, et al. 2006. Blood 107:2030
4. Bottino C, et al. 2003. J. Exp. Med. 198:557
Gene ID: 5819 View all products for this Gene ID
UniProt: View information about CD112 on UniProt.org

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