PE anti-human CD112 (Nectin-2) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25tests	￥ 1638	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation

The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.

Concentration

Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.

Excitation Laser

Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes

Additional reported applications include: partially block CD226-Fc binding to CD112 transfectant cells and partially inhibit the cytotoxicity mediated by NK and T cells.

Application References (PubMed link indicates BioLegend citation)

Tahara-Hanaoka S, et al.. 2004. Int. Immunol. 16:533
Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
Gillory LA, 2013. PLoS One. 8:77753. PubMed

Product Citations

Afolabi LO, et al. 2021. Front Immunol. 12:701671. PubMed
Cordeau M, et al. 2016. PLoS One. 11:e0164401. PubMed
Poznanski SM, et al. 2018. Cancer Immunol Res. 1.065277778. PubMed
Grandclaudon M, et al. 2019. Cell. 179:432. PubMed
Lim O, et al. 2013. PLoS One. 8:e53611. PubMed
Gillory L, et al. 2013. PLoS One. 8:77753. PubMed
Kaito Y, et al. 2022. Oncol Lett. 23:51. PubMed
Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
Siew Y, et al. 2015. Int Immunol. 27: 621 - 632. PubMed

RRID

AB_2174163 (BioLegend Cat. No. 337409) AB_2269088 (BioLegend Cat. No. 337410)

Antigen Details

Structure: Type I transmembrane glycoprotein, Ig superfamily
Distribution: Myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34-positive stem cells, endothelial cells, epithelial cells, and neuronal cells.
Function: Adhesion, receptor for some Herpes Viruses
Ligand/Receptor: CD226, CD155, Nectin-1, -3, and -4, Herpes Viruses
Cell Type: Dendritic cells, Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors, Mast cells, Megakaryocytes
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Synaptic Biology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Zola H et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Bachelet I, et al. 2006. J. Bio. Chem. 281:27190
3. Pende D, et al. 2006. Blood 107:2030
4. Bottino C, et al. 2003. J. Exp. Med. 198:557
Gene ID: 5819 View all products for this Gene ID
UniProt: View information about CD112 on UniProt.org

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