PE anti-human CD257 (BAFF, BLYS) Antibody
- 产品名称：
- PE anti-human CD257 (BAFF, BLYS) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 318606
- 产品应用：
- 318606
[价格]
| 规格 |
价格 |
库存 |
| 100tests |
￥ 4438 |
1 |
- Verified Reactivity
- Human
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- recombinant human BAFF(TL7) protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Product Citations
-
- Vanoni G, et al. 2021. eLife. 10:00. PubMed
- RRID
- AB_830752 (BioLegend Cat. No. 318605) AB_830753 (BioLegend Cat. No. 318606)
- Structure
- Type II transmembrane protein, member of the tumor necrosis factor ligand superfamily. Can be proteolytically cleaved to form soluble protein. Forms homotrimers; predicted molecular weight of monomer approximately 31 kD.
- Distribution
-
Peripheral blood B and T lymphocytes, monocytes, macrophages, dendritic cells. Upregulated by IFN-γ downregulated by PMA/ionomycin treatment
- Function
- Stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors. Prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).
- Ligand/Receptor
- BAFF binds to TACI (TNFRSF13B) and BCMA (TNFRSF17) as does the APRIL ligand. BAFF also binds to the BAFF-specific receptor (BAFFR/BR3)
- Cell Type
- B cells, Dendritic cells, Macrophages, Monocytes, T cells
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Signal Transduction, Stem Cells
- Molecular Family
- CD Molecules, Cytokines/Chemokines, Growth Factors, Soluble Receptors
- Antigen References
-
1. Schneider P, et al. 1999. J. Exp. Med. 189:1747.
2. Moore PA, et al. 1999. Science 285:260.
3. Shu HB, et al. 1999. J. Leuko. Biol. 65:680.
4. Yu G, et al. 2000. Nat. Immunol. 1:252.
5. Oren DA, et al. 2002. Nat. Struct. Biol. 9:288.
- Gene ID
- 10673 View all products for this Gene ID
- UniProt
- View information about CD257 on UniProt.org
