Purified anti-human CD354 (TREM-1) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3206	1

Product Details

Verified Reactivity

Human

Reported Reactivity

African Green, Baboon, Cynomolgus, Rhesus

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant human TREM-1

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
WB - Verified

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

ELISA Detection: The biotinylated TREM-26 antibody is useful as a detection antibody for a TREM-1 specific sandwich ELISA, when used in conjunction with the TREM-37 antibody (Cat. No. 316102) as the capture antibody. The TREM-26 antibody is useful for flow cytometry and activation of monocytes and granulocytes. The Ultra-LEAF? purified antibody (Endotoxin < 0.01 EU/?g, Azide-Free, 0.2 ?m filtered) is recommended for functional assays (Cat. No. 314913 & 314914).

Application References (PubMed link indicates BioLegend citation)

Li J, et al. 2011. Dev. Comp. Immunol. epub.

Product Citations

Dutertre CA, et al. 2020. Immunity. 51(3):573-589.e8.. PubMed

RRID

AB_389213 (BioLegend Cat. No. 314902)

Antigen Details

Structure: Type I membrane protein, 30 kD, contains immunoglobulin-like V-type domain. Alternatively spliced variant may be secreted.
Distribution: Highly expressed in adult liver, lung, and spleen, lower expression in lymph node, placenta, spinal cord, and heart. High expression in peripheral blood myeloid cells.
Function: Stimulates neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines and the upregulation of surface activation markers. Amplifies inflammatory responses to fungal and bacterial
Interaction: DAP12
Modification: Glycosylated
Cell Type: Neutrophils
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family: CD Molecules, Cytokines/Chemokines
Antigen References: 1. Bouchon A, et al. 2001. Nature 410:1103.
2. Bouchon A, et al. 2000. J. Immunol. 164:4991.
3. Gingras MC, et al. 2002. Mol. Immunol. 38:817.
Regulation: Upregulated by bacteria, fungi, and LPS
Gene ID: 54210 View all products for this Gene ID
UniProt: View information about CD354 on UniProt.org

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