PE anti-human CD283 (TLR3) Antibody
- 产品名称：
- PE anti-human CD283 (TLR3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 315009
- 产品应用：
- 315009
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2142 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human Toll-like receptor 3 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: Western bloting. The fluorochrome-labeled TLR-104 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis. For intracellular staining protocol, please visit www.biolegend.com and click on the support tab.
- Application References
(PubMed link indicates BioLegend citation) -
- Fiala M, et al. 2007. P. Natl. Acad. Sci. USA 10.1073/P. Natl. Acad. Sci. USA.0701267104.
- Kong KF, et al. 2008. J. Virol. 82:7613. PubMed
- Sadik CD, et al. 2009. Nucleic Acids Res. 37:5041. PubMed
- Product Citations
-
- Paris O, et al. 2022. Front Immunol. 13:975910. PubMed
- Swartz AM, et al. 2022. Curr Protoc. 2:e410. PubMed
- RRID
- AB_2728267 (BioLegend Cat. No. 315009) AB_2728268 (BioLegend Cat. No. 315010)
- Structure
- Toll-like receptor family member, type I membrane protein containing multiple leucine repeats and a interleukin-1 receptor like region in the extracellular domain, predicted molecular weight approximately 104 kD
- Distribution
-
Selective expression in dendritic cells. Highly expressed in placenta, pancreas, also expressed in heart, liver, lung and muscle
- Function
- Pattern recognition receptor that participates in innate immune response to microbial pathogens. TLR3 ligands induce NF-κB (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 stimulation results in the production of the cytokines
- Interaction
- MYD88, TRAF6, TRIAD3, MAP3K7, TAB2
- Ligand/Receptor
- Polyinosine-polycytidylic acid (Poly(I:C)), dsRNA
- Cell Type
- Dendritic cells
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
-
1. Alexopoulou L, et al. 2001. Nature 413:732.
2. Doyle SE, et al. 2002. Immunity 17:251.
3. Meylan E, et al. 2004. Nature Immun. 5:503.
4. Muzio M, et al. 2000. J. Immunol. 164:5998.
5. Rock FL, et al. 1998. Proc. Natl. Acad. Sci. 95:588.
- Gene ID
- 7098 View all products for this Gene ID
- UniProt
- View information about CD283 on UniProt.org
