Purified anti-Tau, 404-441 Antibody (Previously Co
- 产品名称：
- Purified anti-Tau, 404-441 Antibody (Previously Co
- 产品类别：
- 抗体
- 产品编号：
- 806604
- 产品应用：
- 806604
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution (no preservatives or carrier proteins).
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Application
-
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per mL.?For immunohistochemistry on?formalin-fixed paraffin-embedded tissue, a concentration range of 1.0 - 10 ?g/mL?is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is effective in immunoblotting (WB), immunohistochemistry on?formalin-fixed paraffin-embedded tissue (IHC-P).
This antibody is reactive to the amino acid sequence 404-441 of human Tau.
- Application References
(PubMed link indicates BioLegend citation) -
- Halford RW and Russell DW. 2009. Proc Natl Acad Sci U S A. 106:3502-6. (WB)
- Hoffmann R, et al. 1997. Biochemistry. 36(26):8114-24.
- Bramblett GT, et al. 1993. Neuron. 10(6):1089-99.
- Bramblett GT, et al. 1992. Lab Invest. 66(2):212-22.
- Kosik KS, et al. 1988. Neuron 1(9):817-25.
- Product Citations
-
- Lo Cascio F, et al. 2020. J Biol Chem. 295:14807. PubMed
- RRID
- AB_2734557 (BioLegend Cat. No. 806604) AB_2564709 (BioLegend Cat. No. 806601)
- Structure
- Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
- Distribution
-
Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
- Function
- Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
- Interaction
- Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Tau
- Antigen References
-
- Meredith JE Jr,?et al.?2013.?PLoS One. 8(10): e76523.?PubMed
- Goodall CA,?et al.?2006.?J. Neurol. Neurosurg. Psychiatry?77(1): 89.?PubMed
- Wang Y, Mandelkow E. 2016.?Nat. Rev. Neurosci. 17(1):5-21.?PubMed
- Gene ID
- 4137 View all products for this Gene ID
- UniProt
- View information about Tau, 404-441 on UniProt.org
