Purified anti-Tau, 15-25 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1568	1

规格

价格

库存

25µg

￥ 1568

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Preliminary assignment of its epitope indicates that it maps to amino acid residues 15-25 on the longest isoform of human Tau.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations

Farmer KM, et al. 2020. Acta Neuropathol Commun. 0.425. PubMed
Lo Cascio F, et al. 2020. J Biol Chem. 295:14807. PubMed

RRID

AB_2728542 (BioLegend Cat. No. 835203) AB_2728543 (BioLegend Cat. No. 835204)

Antigen Details

Structure

Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.

Distribution

Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.

Function

Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Interaction

Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, casein kinase I isoform delta, serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.

Biology Area

Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

Tau

Antigen References