Purified anti-Tau, 210-230 Antibody (Previously Co-上海雅吉生物科技有限公司

规格	价格	库存
50µL	￥ 1568	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution (no preservatives or carrier proteins).

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/mL

Storage & Handling

Do not store antibody diluted below 50 ?g/mL. The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application

WB - Quality tested
IHC-P - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 1.0 ?g/mL.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is specific for an epitope that lies between amino acids 210-230 of human Tau.

Application References (PubMed link indicates BioLegend citation)

Lasagna-Reeves CA, et al. 2012. FASEB J. 26:1946. (WB, IHC-P) Pubmed
Horowitz PM, et al. 2004. J Neurosci. 24:7895. (WB)

Product Citations

Franklin W, et al. 2019. Sci Rep. 9:8228. PubMed
Montalbano M, et al. 2020. Neurobiol Dis. 146:105130. PubMed
Kim HS, et al. 2017. Mol Med Rep. 15:3301. PubMed
Abdelhamid M, et al. 2021. J Alzheimers Dis. 85:1555. PubMed
Sengupta U, et al. 2017. Ann Clin Transl Neurol. 10.1002/acn3.382. PubMed
Choi YB, et al. 2021. Alzheimers Res Ther. 13:32. PubMed
Sengupta U, et al. 2020. Mol Neurobiol. 57:2741. PubMed
Lo Cascio F, et al. 2019. Sci Rep. 9:19011. PubMed
Puangmalai N, et al. 2020. Cell Death Dis. 11:314. PubMed
Guix FX, et al. 2018. Int J Mol Sci. 13:e0199785. PubMed
Lo Cascio F, et al. 2020. J Biol Chem. 295:14807. PubMed

RRID

AB_2715857 (BioLegend Cat. No. 806404) AB_2564705 (BioLegend Cat. No. 806401) AB_2564706 (BioLegend Cat. No. 806402) AB_2564704 (BioLegend Cat. No. 806403)

Antigen Details

Structure: Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Distribution: Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
Function: Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Interaction: Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
Cell Type: Neurons
Biology Area: Cell Biology, Cell Proliferation and Viability, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Synaptic Biology
Molecular Family: Tau
Gene ID: 4137 View all products for this Gene ID
UniProt: View information about Tau 210-230 on UniProt.org

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