Purified anti-Tau, 6-18 Antibody (Previously Covan-上海雅吉生物科技有限公司

规格	价格	库存
25µL	￥ 1568	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution (no preservatives or carrier proteins).

Preparation

The antibody was purified by affinity chromatography.

Concentration

1 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.

Application

WB - Quality tested
IHC-P, ELISA - Verified

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.01 - 0.05 ?g per ml.?For immunohistochemistry, a concentration range of 0.01 - 0.05 ?g/ml is suggested. For ELISA applications, a concentration range of 10 - 100 ng/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is specific for an epitope that lies between amino acids 6-18 of human Tau.

Application References (PubMed link indicates BioLegend citation)

Irwin D, et al. 2012. Brain. 135(Pt 3):: 807. (IHC-P) PubMed
Horowitz PM, et al. 2004. J Neurosci. 24(36):7895 (WB)
Sengupta U, et al. 2017. Ann Clin Transl Neurol. 4(4):226. (WB) PubMed
Meredith JE, et al. 2013. PLoS One. 7;8(10):e76523 (ELISA, WB) PubMed
Song L, et al. 2015, Mol Neurodegener. 10:14 (ELISA, WB) PubMed

Product Citations

Ashton NJ, et al. 2022. EBioMedicine. 76:103836. PubMed
Chatterjee S, et al. 2022. Sci Adv. 8:eabm6063. PubMed
Ercan E, et al. 2017. Mol Neurodegener. . 10.1186/s13024-017-0229-1. PubMed
Haenig C, et al. 2020. Cell Rep. 32:108050. PubMed
Karikari TK, et al. 2020. Lancet Neurol. 422:19. PubMed
Serafín V, et al. 2020. Anal Bioanal Chem. 413:799. PubMed
Milà-Alomà M, et al. 2022. Nat Med. :. PubMed
Sengupta U, et al. 2017. Ann Clin Transl Neurol. 10.1002/acn3.382. PubMed
Karikari TK, et al. 2020. ACS Chem Neurosci. 2.622916667. PubMed
Karikari TK, et al. 2020. Alzheimers Dement. 17:755. PubMed
Bichmann M, et al. 2021. Mol Neurodegener. 16:46. PubMed

RRID

AB_2715842 (BioLegend Cat. No. 806503) AB_2564707 (BioLegend Cat. No. 806501) AB_2564708 (BioLegend Cat. No. 806502)

Antigen Details

Structure: Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Distribution: Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
Function: Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Interaction: Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Tau
Antigen References: 1. Meredith JE Jr, et al. 2013. PLoS One. 8(10): e76523. PubMed
2. Goodall CA, et al. 2006. J. Neurol. Neurosurg. Psychiatry 77(1): 89. PubMed
3. Wang Y, Mandelkow E. 2016. Nat. Rev. Neurosci. 17(1):5-21.?PubMed
Gene ID: 4137 View all products for this Gene ID
UniProt: View information about Tau, 6-18 on UniProt.org

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