Biotin anti-Tau, 6-18 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1904	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide

Preparation

The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.

Concentration

0.5 mg/mL

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

Application

IHC-P - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 1.0 ?g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody is specific for an epitope that lies between amino acids 6-18 of human Tau.

Application References (PubMed link indicates BioLegend citation)

Irwin D, et al. 2012. Brain. 135(Pt 3):: 807. (IHC-P) PubMed
Horowitz PM, et al. 2004. J Neurosci. 24(36):7895 (WB)
Sengupta U, et al. 2017. Ann Clin Transl Neurol. 4(4):226. (WB) PubMed
Meredith JE, et al. 2013. PLoS One. 7;8(10):e76523 (ELISA, WB) PubMed
Song L, et al. 2015, Mol Neurodegener. 10:14 (ELISA, WB) PubMed

RRID

AB_2861079 (BioLegend Cat. No. 806505) AB_2861080 (BioLegend Cat. No. 806506)

Antigen Details

Structure: Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Distribution: Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
Function: Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Interaction: Tau interacts with: Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Tau
Antigen References: 1. Meredith JE Jr, et al. 2013. PLoS One. 8(10): e76523. PubMed
2. Goodall CA, et al. 2006. J. Neurol. Neurosurg. Psychiatry 77(1): 89. PubMed
3. Wang Y, Mandelkow E. 2016. Nat. Rev. Neurosci. 17(1):5-21.?PubMed
Gene ID: 4137 View all products for this Gene ID
UniProt: View information about Tau, 6-18 on UniProt.org

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