Biotin anti-human CD258 (LIGHT) Antibody
- 产品名称：
- Biotin anti-human CD258 (LIGHT) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 318704
- 产品应用：
- 318704
- Verified Reactivity
- Human
- Reported Reactivity
- Rhesus
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- recombinant human LIGHT (TL5) protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_830862 (BioLegend Cat. No. 318704)
- Structure
- Type 2 transmembrane protein, member of the tumor necrosis factor ligand superfamily. Can be proteolytically cleaved; two isofoms produced by alternative splicing. Apparent molecular weight approximately 30 kD.
- Distribution
-
Spleen, brain and kidney. Upregulated on activated T cells (particularly CD8+ cells)
- Function
- Stimulates proliferation of T cells, inhibits growth of some tumor cells. Has been shown to play a role in intestinal inflammation and contribute to IgA nephropathy
- Interaction
- TRAF2, TRAF3, DIABLO
- Ligand/Receptor
- Ligand for HVEM, LTβR. Has also been shown to bind DcR3
- Cell Type
- T cells
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Mauri DN, et al. 1998. Immunity 8:21.
2. Harrop JA, et al. 1998. J. Biol. Chem. 273:27548.
3. Morel Y, et al. 2000. J. Immunol. 165:4397.
4. Wang J, et al. 2004. J. Clin. Invest. 113:826.
5. Yu P, et al. 2004. Nature Immunol. 5:141.
- Gene ID
- 8740 View all products for this Gene ID
- UniProt
- View information about CD258 on UniProt.org
