Purified anti-TRF2 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
100µg	￥ 3542	1

规格

价格

库存

100µg

￥ 3542

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Full length TRF2 protein produced in baculovirus.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: TRF2 has 6 isoforms. Clone T2JKM3 recognizes multiple isoforms based on the homology of immunogen sequence. Clone T2JKM3 does not cross-react with mouse (in-house tested).
RRID: AB_2632764 (BioLegend Cat. No. 692402)

Structure: 542 amino acids with a predicted molecular weight of 59.6 kD.
Distribution: Nucleus.
Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes.
Interaction: Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP/RAP1, ACD and POT1. Interacts with TERF2IP, NBN, SLX4/BTBD12, DCLRE1B/Apollo and TERF2IP/RAP1.
Biology Area: Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication
Antigen References: 1. Griffith JD, et al. 1999. Cell. 97:503.
2. van Steensel B, et al. 1998. Cell. 92:401.
3. Palm W, de Lange T. 2008. Annu. Rev. Genet. 42:301.
4. Bilaud T, et al. 1997. Nat. Genet. 17:236.
5. Sfeir A, de Lange T. 2012. Science 336:593.
6. Bellon M, et al. 2006. Int. J. Cancer 119:2090.
7. Benhamou Y, et al. 2016. Oncotarget. doi: 10.18632/oncotarget.10005.
Gene ID: 7014 View all products for this Gene ID
UniProt: View information about TRF2 on UniProt.org