Purified anti-NAC-1 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1484	1

Product Details

Verified Reactivity

Human

Antibody Type

Monoclonal

Host Species

Mouse

Immunogen

Recombinant NAC-1 protein.

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

IHC-P - Quality tested
WB - Verified
FC, ICC, IP - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 ?g/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 10 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: flow cytometric analysis¹, immunofluorescence microscopy¹, and immunoprecipitation¹.

Application References (PubMed link indicates BioLegend citation)

Nakayama K, et al. 2006. Proc. Natl. Acad. Sci. USA 103(49):18739. (IP, WB, IHC, IF) PubMed

RRID

AB_2650705 (BioLegend Cat. No. 849301) AB_2650706 (BioLegend Cat. No. 849302)

Antigen Details

Structure: NAC-1 is a 527 amino acid protein with an apparent molecular mass of 57.3 kD.
Distribution: Tissue distribution: brain, ovary, testis, and thyroid.
Cellular distribution: nucleus and cytosol.
Function: NAC-1 is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. NAC-1 also contributes to the progression of multiple types of cancer by suppressing the transcription of the tumor suppressor Gadd45GIP1. It also functions as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4.
Ligand/Receptor: Interacts with other POZ/BTB proteins, HDACs, CUL3, PSMD7, RCOR1.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
Antigen References: 1. Mackler SA, et al. 2000. J. Neurosci. 20:6210-7. PuMed
2. Korutla L, et al. 2009. Neurochem. Int. 54:245-52. PubMed
3. Korutla L, et al. 2003. Neurosci. Res. 46(1):33-9. PubMed
Gene ID: 112939 View all products for this Gene ID
UniProt: View information about NAC-1 on UniProt.org

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