Purified anti-Tau, 95-108 (PHF) Antibody -上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1484	1

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: WB - Quality tested
IHC-P - Verified
Recommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 ?g per ml.?For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration of 5.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: SMI 51 reacts with microtubule-associated protein tau independently of its degree of phosphorylation. This antibody reacts strongly with paired helical filaments in Alzheimer disease while its reaction with Tau in normal human tissue is relatively weak. The antibody recognizes the 95 to 108 sequence of Tau (AGIGDTSNLEDQAA) in a conformation partially dependent on serine in position 101.
RRID: AB_2801172 (BioLegend Cat. No. 836103) AB_2801173 (BioLegend Cat. No. 836104)

Structure: Unmodified Tau isoforms have an apparent molecular weight ranging from 33-79 kD. Additional high and low molecular weight Tau species have been observed in brain tissues.
Distribution: Tissue distribution: Central nervous system, peripheral ganglia and nerves, kidney, skeletal, and heart muscle.
Cellular distribution: Cytoskeleton, nucleus, plasma membrane, and cytosol.
Function: Tau promotes microtubule assembly and stability. The short tau isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Interaction: Tau interacts with Sequestosome-1, Peptidyl-prolyl cis-trans isomerase FKBP4, Casein kinase I isoform delta, Serine/threonine-protein kinase Sgk1, Laforin, and alpha-synuclein.
Biology Area: Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family: Tau
Gene ID: 4137 View all products for this Gene ID
UniProt: View information about Tau, 95-108 on UniProt.org