PE anti-human CD328 (Siglec-7) Antibody
- 产品名称：
- PE anti-human CD328 (Siglec-7) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 347703
- 产品应用：
- 347703
[价格]
| 规格 |
价格 |
库存 |
| 25tests |
￥ 2478 |
1 |
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Siglec-7 3T3 transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 ?l per million cells in 100 ?l staining volume or 5 ?l per 100 ?l of whole blood.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: Blocking2.
- Application References
(PubMed link indicates BioLegend citation) -
- Nicoll G, et al. 1999. J. Biol Chem. 274:34089.
- Hudak J, et al. 2014. Nat. Chem Biol. 10:69–75.
- RRID
- AB_2189410 (BioLegend Cat. No. 347703)
- Structure
- Type I transmembrane protein, Siglec family member, 75 kD
- Distribution
-
Monocytes, NK cells
- Function
- Inhibitory receptor of NK cells
- Interaction
- After tyrosine phosphorylation interacts with PTPN6 and SHP-1
- Ligand/Receptor
- Sialylated glycans (with α,8 disialyl and α2,6 sialyl residues)
- Bioactivity
- Inhibition of signal transduction by recruiting cytoplasmic phosphatases
- Cell Type
- Monocytes, NK cells
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules, Siglec Molecules
- Antigen References
-
1. Avril T, et al. 2006. Infect Immun. 74:4133.
2. Avril T, et al. 2006. J. Leukoc. Biol. 80:787.
3. Orr SJ, et al. 2007. J. Biol Chem. 282:3418.
4. Brunetta E, et al. 2009. Blood 114:3822.
- Gene ID
- 27036 View all products for this Gene ID
- UniProt
- View information about CD328 on UniProt.org
