Purified anti-SIK2 Antibody
- 产品名称：
- Purified anti-SIK2 Antibody
- 产品类别：
- 抗体
- 产品编号：
- 636702
- 产品应用：
- 636702
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human SIK2
- Molecular Mass
- 104
- Formulation
- This antibody is prodived in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted?between 2°C and 8°C.
- Application
-
WB - Quality tested
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested working dilution is 1:250. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Bon H, et al. 2015. Mol Cancer Res. 13:620. PubMed
- Product Citations
-
- Bon H, et al. 2015. Mol Cancer Res. 13:620. PubMed
- Maxfield K, et al. 2016. Mol Cell Biol. 36(24):3048-3057. PubMed
- RRID
- AB_2187452 (BioLegend Cat. No. 636702)
- Structure
- Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and AMP-activated protein kinase (AMPK) subfamily. SIK2 contains 1 protein kinase domain and 1 UBA domain.
- Interaction
- IRS 1, TORC2
- Bioactivity
- Involved in metabolic regulation in adipose tissue. Sik2 phosphorylates ser794 of human insulin receptor substrate-1(IRS1) in insulin-stimulated adipocytes, playing important roles in modulating the insulin-signaling cascade of adipocytes.
- Biology Area
- Cell Biology, Signal Transduction
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
-
1. Horike N, et al. 2003. J. Biol. Chem. 278:18440.
- Gene ID
- 23235 View all products for this Gene ID
- UniProt
- View information about SIK2 on UniProt.org
