Purified anti-mouse CD43 Antibody -上海雅吉生物科技有限公司

规格	价格	库存
50µg	￥ 910	1

Product Details

Verified Reactivity

Mouse

Antibody Type

Monoclonal

Host Species

Rat

Immunogen

Mouse plasmacytoma cells

Formulation

Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation

The antibody was purified by affinity chromatography.

Concentration

0.5 mg/ml

Storage & Handling

The antibody solution should be stored undiluted between 2°C and 8°C.

Application

FC - Quality tested
WB - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 ?g per million cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: Western blotting³. The S11 antibody reacts with pan-CD43.

Application References (PubMed link indicates BioLegend citation)

Gaspari AA, et al. 1993. J. Invest. Dermatol. 100:247. (FC)
Merzaban JS, et al. 2005. J. Immunol. 174:4051. (FC)
Baecher-Allan CM, et al. 1993. Immunogenetics. 37:183. (WB)

Product Citations

Blriot C, et al. 2021. Immunity. :. PubMed
Gubin MM, et al. 2018. Cell. 175:1014. PubMed
McClellan BL, et al. 2022. STAR Protoc. 3:101357. PubMed

RRID

AB_11125579 (BioLegend Cat. No. 143201) AB_11124103 (BioLegend Cat. No. 143202)

Antigen Details

Structure: Single chain of type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites; 115 kD and 130 kD glycoforms with different glycosylation and sialylation.
Distribution: Gamma/delta T cells, macrophages, mature B cells, and dendritic cells.
Function: Plays dual roles in cell-cell adhesion and anti-adhesion, costimulation of cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors.
Interaction: CD43 functions as an anti-adhesive surface molecule, promoted by antibody cross-linking, that releases the trailing edge of the cell during locomotion to allow movement of the cell body towards the lamellipodia.
Ligand/Receptor: Moesin, CD54, E-selectin, Siglec-1.
Cell Type: B cells, Dendritic cells, Macrophages, T cells
Biology Area: Cell Adhesion, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Van den Berg TK, et al. 2001. J. Immunol. 166:3637.
2. Moore T, et al. 1994. J. Immunol. 153:4978.
3. Onami TM, et al. 2002. J. Immunol. 168:6022.
4. Tong J, et al. 2004. J. Exp. Med. 199:1277.
5. Jones AT, et al. 1994. J. Immunol. 153:3426.
6. Matsumoto M, et al. 2005. J. Immunol. 175:8042.
Gene ID: 20737 View all products for this Gene ID
UniProt: View information about CD43 on UniProt.org

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