PE anti-mouse CD276 (B7-H3) Antibody
- 产品名称：
- PE anti-mouse CD276 (B7-H3) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 124507
- 产品应用：
- 124507
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Xu J, et al. 2006. Cellular and Molecular Immunology. 3(3):235
- Prasad D.V.R. 2004. J.Immunology.173:2500
- Product Citations
-
- Chen L, et al. 2020. Cancer Immunol Res. 0.457638889. PubMed
- Wolock SL, et al. 2019. Cell Rep. 28:302. PubMed
- Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
- O'Hara J, et al. 2012. Infect Immun. 80:1563. PubMed
- RRID
- AB_1279208 (BioLegend Cat. No. 124507) AB_1279206 (BioLegend Cat. No. 124508)
- Structure
- About 49.7 kd transmembrane protein characterized by extracellular IgV and IgC domains.
- Distribution
-
Mouse B7-H3 is expressed on professional APCs, including B cells, dendritic cells, and macrophages. It is reported to express on a minor fraction of CD4+ and CD8+ cells.
- Ligand/Receptor
- The receptor has not been identified, but it seems to be expressed on activated T cells.
- Bioactivity
- Mouse B7-H3 is a negative regulator of T cell activation and IL-2 production.
- Cell Type
- Antigen-presenting cells, Dendritic cells
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. Sun M et al. 2002. J. Immunology. 168:6294
2. Xu J et al. 2006. Cellular and Molecular Immunology. 3(3):235
- Gene ID
- 102657 View all products for this Gene ID
- UniProt
- View information about CD276 on UniProt.org
