Purified anti-RORγ Antibody
- 产品名称：
- Purified anti-RORγ Antibody
- 产品类别：
- 抗体
- 产品编号：
- 646501
- 产品应用：
- 646501
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Armenian Hamster
- Immunogen
- Mouse RORγ
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 ?g per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
(PubMed link indicates BioLegend citation) -
- Sun Z, et al. 2000. Science 288:2369
- Product Citations
-
- Onder L et al. 2017. Immunity. 47(1):80-92 . PubMed
- Chen HL, et al. 2021. Pharm Biol. 59:134. PubMed
- Morita Y, et al. 2022. Bone Res. 10:56. PubMed
- RRID
- AB_2180302 (BioLegend Cat. No. 646501) AB_2238503 (BioLegend Cat. No. 646502)
- Structure
- RORγ has two isoforms: RORγ1 and RORγ2 (also known as RORγt). RORγ1 contains 516 amino acids and RORγt contains 495 amino acids (RORγt lacks the amino terminus).
- Distribution
-
RORγ1 is expressed in thymus, kidney, liver, muscle and brown fat tissue but not white fat tissue. RORγt is specifically expressed in CD4+/CD8+?double positive thymocytes, Th17 cells and lymphoid tissue inducers (LTi).
- Function
- RORγ plays critical roles during thymopoiesis, T cell homeostasis, lymph nodes and Peyers patch development. Among two isoforms, RORγt is well studied and it promotes thymocyte differentiation into pro-inflammatory Th17 cells.
- Cell Type
- Thymocytes
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- Nuclear Markers
- Antigen References
-
1. Medvedev A, et al. 1997. Genomics 46:93.
2. He YW, et al. 1998. Immunity 9:797.
3. Eberl G, et al. 2004. Nat. Immunol. 5:64.
- Gene ID
- 19885 View all products for this Gene ID
- UniProt
- View information about ROR gamma on UniProt.org
