PE anti-mouse CD365 (Tim-1) Antibody
- 产品名称：
- PE anti-mouse CD365 (Tim-1) Antibody
- 产品类别：
- 抗体
- 产品编号：
- 119505
- 产品应用：
- 119505
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per 106 cells in 100 ?l volume. It is recommended that the reagent be titrated for optimal performance in each application.
- Excitation Laser
- Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application References
(PubMed link indicates BioLegend citation) -
- Meyers JH, et al. 2005. Nat. Immunol. 6:455.
- Nakae S, et al. 2007. Blood doi:10.1182/blood-2006-11-058800.
- Yamanishi Y, et. al. 2010. J. Exp. Med. 207:1501. (FC)
- Namavari A, et al. 2012. Invest Ophthalmol Vis Sci. 53:4575. PubMed.
- Product Citations
-
- Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
- Mirshahi F, et al. 2022. Cell Rep. 38:110454. PubMed
- Khiew SH, et al. 2020. J Clin Invest. 130:3453. PubMed
- Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
- Nagahara K, et al. 2008. J Immunol. 181:7660. PubMed
- Xiao S, et al. 2020. Cell Reports. 32(2):107892. PubMed
- Kimura S, et al. 2020. Am J Transplant. 20:977. PubMed
- RRID
- AB_2248167 (BioLegend Cat. No. 119505) AB_2232887 (BioLegend Cat. No. 119506)
- Structure
- Transmembrane protein containing immunoglobulin domain and mucin-like domain; predicted molecular weight 33 kD.
- Distribution
-
Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.
- Function
- Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
- Ligand/Receptor
- Binds hepatitis A virus in humans, Tim-4, LMIR5/CD300b
- Cell Type
- T cells, Th2
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
-
1. McIntire JJ, et al. 2001. Nature Immunol. 2:1109.
2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69.
4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.
- Gene ID
- 171283 View all products for this Gene ID
- UniProt
- View information about CD365 on UniProt.org
