Purified anti-mouse CD88 (C5aR) Recombinant Antibo
- 产品名称：
- Purified anti-mouse CD88 (C5aR) Recombinant Antibo
- 产品类别：
- 抗体
- 产品编号：
- 165502
- 产品应用：
- 165502
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 ?g per million cells in 100 ?L volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2927837 (BioLegend Cat. No. 165502)
- Structure
- CD88 is a single chain protein with seven membrane-spanning regions, 43 kD
- Distribution
-
Neutrophils, eosinophils, monocytes, glial cells, cerebellar granule cells, cardiomyocytes and vascular endothelial cells
- Function
- After C5a binding, the CD88 signal results in chemotaxis, granule enzyme release and superoxide anion production.
- Interaction
- CD88 is coupled to heterotrimeric G proteins such as Gi, the signal transduced by CD88 results in the activation of PLCβ, PI-3 kinase, PLA2 among other molecules.
- Ligand/Receptor
- C5a, one of the products of the cleavage of C5 by the C5 convertase complex (C4bC3bC2a or C3bC3bBb)
- Cell Type
- Dendritic cells, Endothelial cells, Eosinophils, Monocytes, Neutrophils
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules
- Antigen References
-
- Schraufstatter IU, et al. 2009. J Immunol. 182:3827-36.?
- Ippel JH, et al. 2009. J Biol Chem. 284:12363-72.
- Monk, PN, et al. 2007. Br J Pharmacol. 152:429-48.
- Griffin RS, et al. 2007. J Neurosci. 27:8699-708.
- Lee H, et al. 2006. Nat Biotechnol. 24:1279-84.
- Buck E and Wells JA. 2005. Proc Natl Acad Sci USA. 102:2719-24.
- Gene ID
- 12273 View all products for this Gene ID
- UniProt
- View information about CD88 on UniProt.org
