Ultra-LEAF™ Purified anti-mouse IL-17A Recom
- 产品名称：
- Ultra-LEAF™ Purified anti-mouse IL-17A Recom
- 产品类别：
- 抗体
- 产品编号：
- 946503
- 产品应用：
- 946503
- Verified Reactivity
- Mouse
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Mouse IL-17A
- Formulation
- 0.2 ?m filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/?g of the protein (< 0.001 ng/?g of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF? (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF? solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by neutralizing the induction of mouse IL-6 by recombinant mouse IL-17A (5 ng/mL) in fetal mouse skin fibroblasts. ND50 range:? 7 – 35 ng/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
- AB_2910507 (BioLegend Cat. No. 946503) AB_2910507 (BioLegend Cat. No. 946504)
- Structure
- Dimer
- Distribution
-
Memory T lymphocytes, CD4+?T helper cells (Th17), neutrophils, CD8(+), NK, and gamma-delta T cells
- Function
- Potent regulator of granulopoiesis and neutrophil recruitment under normal and inflammatory conditions. Its organ overexpression increases circulating neutrophil numbers and recruitment into the organs by induction of CXCL2, IL-1β, and G-CSF. Induces CXCL1, CXCL2, CXCL5, and CXCL8 in human epithelial cells. Cooperates with TLR ligands, IL-1β, and TNF-α to enhance inflammatory reactions and stimulate production of β-defensins and other antimicrobial peptides. Th17 differentiation of human and murine na?ve T cells is markedly suppressed in the presence of IFNα.
- Interaction
- Epithelial cells, fibroblasts, B and T lymphocytes, myelomonocytic cells, and marrow stromal cells
- Ligand/Receptor
- Heteromeric receptor composed of IL-17RA and IL-17RC
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
- Yu J, et al. 2008. Front Biosci.?13:170-7.
- Toy D, et al.?2006. J?Immunol. 177:36-9.
- Benghiat FS, et al. 2009. Transplant Rev. 23:11-8.
- Honorati MC, et al. 2001. Rheumatology. 40:522-7.
- Rouvier E, et al.?1993. J Immunol. 150:5445-56.
- Liang SC, et al. 2007. J?Immunol. 179:7791-9.
- Ouyang W, et al. 2008. Immunity. 28:454-67.
- Gene ID
- 16171 View all products for this Gene ID
- UniProt
- View information about IL-17A on UniProt.org
