Purified anti-β-Amyloid, x-40 Recombinant Ant-上海雅吉生物科技有限公司

规格	价格	库存
25µg	￥ 1806	1

Product Details

Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Rabbit
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: IHC-P - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.1 - 1.0 ?g/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone QA18A67 is reactive to the c-terminus of ?-amyloid and specific for the isoform that ends at the 40th amino acid.

This clone demonstrates preference for ?-amyloid x-40 peptide with minimal cross-reactivity to the x-42 peptide.
RRID: AB_2810805 (BioLegend Cat. No. 867801) AB_2810806 (BioLegend Cat. No. 867802)

Antigen Details

Structure

Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.

Distribution

Tissue sources: Primarily nervous system, but also adipose tissue, intestine, and muscle.
Distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and Golgi apparatus.

Function

The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.

Interaction

Tau, prion, α2-macroglobulin, apoE and apoJ, toll-like receptor 2 (TLR2), TLR4, TLR6, and their co-receptors CD14, CD36, and CD47.

Ligand/Receptor

Receptor for advanced glycation end products (RAGE), low-density lipoprotein receptor-related protein 1 (LRP1), glycoprotein 330 (gp330/megalin), P-glycoprotein.

Cell Type

Neurons

Biology Area

Neurodegeneration, Neuroinflammation, Neuroscience, Protein Misfolding and Aggregation

Molecular Family

APP/β-Amyloid, APP/Aβ Degradation

Antigen References