Purified anti-Huntingtin Recombinant Antibody
- 产品名称：
- Purified anti-Huntingtin Recombinant Antibody
- 产品类别：
- 抗体
- 产品编号：
- 948901
- 产品应用：
- 948901
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Partial recombinant human Huntingtin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 5.0??g/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Signals were detected on FFPE human brain tissues using this antibody.
- RRID
- AB_2904463 (BioLegend Cat. No. 948901) AB_2904463 (BioLegend Cat. No. 948902)
- Structure
- Huntingtin is a 3,144 amino acid protein with a molecular mass of 348 kD.
- Distribution
-
Brain and peripheral nerves/Neuronal cells
- Function
- HTT protein maintains tissue homeostasis by regulating vesicular transport and recycling, cell division, ciliogenesis, endocytosis, autophagy, and gene transcription.
- Interaction
- HTT protein interacts with dynein/dynactin for vesicle transport and cell division, Hip1 for endocytosis, GTPase Rab11 for vesicle recycling, p62 for autophagy induction, and CBP, NeuroD, SP1, NF-κB, p53 for transcriptional regulations.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience
- Molecular Family
- Microtubules, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Leavitt BR, et al. 2020. JAMA Neurol. 77:764-772.
- McColgan P, et al. 2019.?Eur J Neurol. 25:24-34.
- Saudou F, et al. 2016.?Neuron.?89:910-26.
- Gene ID
- 3064 View all products for this Gene ID
- UniProt
- View information about Huntingtin on UniProt.org
